Puberty Syndrome, a mysterious and supernatural condition thought to be a myth, affects only teenagers and manifests symptoms that are often dismissed as not real. Yet, Sakuta Azusagawa, a high school student, has encountered it firsthand and notices it’s surprisingly common at his school.
Mai Sakurajima, once a celebrated child actress, has paused her acting career for undisclosed reasons. Now in her third year of high school, she carries an aura that keeps others at a distance. That changes when Sakuta spots her in a bunny girl outfit in the library, invisible to everyone but him. He discovers she is suffering from Puberty Syndrome and decides to assist her. His efforts to help Mai lead him to meet other girls dealing with the same baffling condition.
[Adapted from MAL]